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What can Megace ES do for me? Taking Megace ES can help increase your appetite and the amount of calories you eat every day so your body gets the nutrients it needs to function. A study showed that over 12 weeks1: • 89% of patients increased their appetite*†1 • Patients increased their daily caloric intake by an average of 30%*1 • Patients showed an average weight gain from baseline of more than 10 lbs at week 12*‡ 1
*The FDA approval of Megace ES was based on its bioequivalence to megestrol acetate oral suspension in fed subjects. Efficacy results for Megace ES are expected to be similar to the results from 2 multicenter, randomized, double-blind efficacy trials comparing megestrol acetate oral suspension 800 mg/20 mL vs. placebo in AIDS patients over a 12-week period.1 † In Trial 1 (n=81), 89% of megestrol acetate–treated patients showed an improvement in appetite at endpoint (12 weeks) vs. 50% for placebo. In Trial 2 (n=65), 67% of megestrol acetate treated patients showed an improvement in appetite at endpoint (12 weeks) vs. 38% for placebo.1 ‡ In Trial 1 (n=81), megestrol acetate–treated patients showed a mean increase of 2.5 lbs in lean body mass and a mean increase of 5.5 lbs in fat mass from baseline, whereas placebo had a mean decrease of 1.7 lbs in lean body mass and no change in fat mass from baseline. In Trial 2 (n=65), there was a mean decrease of 0.6 lbs in lean body mass and a mean increase of 5.7 lbs in fat mass from baseline, whereas placebo had a mean decrease of 1.6 lbs in lean body mass and a mean increase of 1.5 lbs in fat mass from baseline.1
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