Megace ES vs. original
formula Megace^®

Megace ES is indicated for the treatment of anorexia, cachexia, or an unexplained, significant weight loss in AIDS patients.¹ A reformulation of megestrol acetate oral suspension, Megace ES has demonstrated improved bioavailability for subjects in the unfed state vs. original formula Megace^®.*^†

Megace ES and original formula Megace are not therapeutic equivalents.³ In addition, there is no generic substitute for Megace ES.³ For AIDS patients who have lost interest in eating or are experiencing unintended weight loss, Megace ES can help them improve their appetite and gain weight, which can lead to an enhanced sense of well-being.¹

Megace ES is unique and differs from original formula Megace in the following ways:

Megace ES is better absorbed

• Megace ES has improved bioavailability in the unfed condition vs. original formula Megace and equivalent bioavailability in the fed condition^†1

• The fed condition is achieved by subjects eating a high-calorie (800-1000 calories) and high-fat (approximately 50% of total calories) meal¹⁶

An FDA example meal shown at right is 2 eggs fried in butter, 2 strips of bacon, 2 slices of toast with butter, 4 ounces of hash brown potatoes, and 8 ounces of whole milk.¹⁶

• Megace ES has improved bioavailability in the unfed condition vs. original formula Megace
and equivalent bioavailability in the fed condition^†1

• The fed condition is achieved by subjects eating a high-calorie (800-1000 calories)
and high-fat (approximately 50% of total calories) meal¹

Less volume and reduced viscosity

Megace ES has 75% less total volume per dose compared with Megace 800 mg/20 mL.^1,17 Megace ES is also 94% less viscous than original formula Megace.⁶ This may be important for patients struggling with their ability and desire to eat.

• Megace ES is substantially less viscous than some common OTC products, including Mylanta^{®‡ 6}

• Lower viscosity may make Megace ES easier to take and may be important for patients who have trouble swallowing

*Megestrol acetate oral suspension.

^†Clinical significance unknown. Megace ES has improved absorption over original formula Megace in people who have not eaten (the unfed state). For people who have eaten (fed condition), Megace ES and original formula Megace have similar absorption into the body. The fed condition is achieved by subjects eating a high-calorie (800-1000 calories) and high-fat (approximately 50% of total calories) meal.¹⁶

^‡Mylanta is a registered trademark of Johnson & Johnson-Merck Consumer Pharmaceuticals Co.